interleukin 18 binding protein

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Ligands
interleukin 18 binding protein (Human)

GtoPdb Ligand ID: 13868

Compound class: Endogenous peptide in human, mouse or rat

Comment: Interleukin 18 binding protein (IL18BP) binds to and inhibits the activity of circulating pro-inflammatory IL-18 at its receptor [3].
Synthetic IL18BP mimetics offer potential anti-inflammatory action for the treatment of inflammation-mediated (and autoimmune) diseases [1-2].

Species: Human

References
1. Jang YS, Lee K, Park M, Joo Park J, Choi GM, Kim C, Dehkohneh SB, Chi S, Han J, Song MY et al.. (2023) Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation. Cytokine, 172: 156413. [PMID:37918054]
2. Novick D. (2024) IL-18 and IL-18BP: A Unique Dyad in Health and Disease. Int J Mol Sci, 25 (24). [PMID:39769266]
3. Park SY, Hisham Y, Shin HM, Yeom SC, Kim S. (2022) Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases. Biomedicines, 10 (7). [PMID:35885055]

References

1. Jang YS, Lee K, Park M, Joo Park J, Choi GM, Kim C, Dehkohneh SB, Chi S, Han J, Song MY et al.. (2023)
Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation.
Cytokine, 172: 156413. [PMID:37918054]

2. Novick D. (2024)
IL-18 and IL-18BP: A Unique Dyad in Health and Disease.
Int J Mol Sci, 25 (24). [PMID:39769266]

3. Park SY, Hisham Y, Shin HM, Yeom SC, Kim S. (2022)
Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases.
Biomedicines, 10 (7). [PMID:35885055]