interleukin 18 binding protein

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Ligands
interleukin 18 binding protein (Human)

GtoPdb Ligand ID: 13868

Compound class: Endogenous peptide in human, mouse or rat

Comment: Interleukin 18 binding protein (IL18BP) binds to and inhibits the activity of circulating pro-inflammatory IL-18 at its receptor [3].
Synthetic IL18BP mimetics offer potential anti-inflammatory action for the treatment of inflammation-mediated (and autoimmune) diseases [1-2].

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Immunopharmacology Comments
Sequesters circulating IL-18 and neutralises IL-18-mediated stimulation of interferon-gamma (IFNγ) production in immune cells.

Immunopharmacology Comments

Sequesters circulating IL-18 and neutralises IL-18-mediated stimulation of interferon-gamma (IFNγ) production in immune cells.