zadoprubart

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Ligands
zadoprubart

GtoPdb Ligand ID: 13799

Comment: Zadoprubart is the INN for an anti-B and T lymphocyte attenuator (BTLA) monoclonal antibody. We have been unable to associate this with a clinical candidate or company research code.

There is information confirming two anti-BTLA monoclonals that were progressed to clinical development: HFB200603 (HiFiBiO; Phase 1 NCT05789069, solid tumours) [2] and ANB032 (AnaptysBio; Phase 2 NCT05935085, atopic dermatitis; terminated due to insufficient efficacy) [1].

Summary
Biological activity
References
Immunopharmacology

Immunopharmacology Comments
Zadoprubart targets B and T lymphocyte attenuator (BTLA) and was developed for potential immune checkpoint inhibitory, immunomodulating and antineoplastic activities.

Immunopharmacology Comments

Zadoprubart targets B and T lymphocyte attenuator (BTLA) and was developed for potential immune checkpoint inhibitory, immunomodulating and antineoplastic activities.