xeligekimab

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Ligands
xeligekimab

GtoPdb Ligand ID: 13784

Synonyms: GR-1501 | GR1501

xeligekimab is an approved drug

Compound class: Antibody

Comment: Xeligekimab (GR1501) is a human IgG4 monoclonal antibody that targets IL-17A [2].

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Monoclonal antibody-mediated neutralisation of pro-inflammatory IL-17A blocks IL-17R activation which inhibits release of cytokines such as CXCL1 and IL-6 that would induce leukocyte infiltration at inflammatory sites.

Immunopharmacology Comments

Monoclonal antibody-mediated neutralisation of pro-inflammatory IL-17A blocks IL-17R activation which inhibits release of cytokines such as CXCL1 and IL-6 that would induce leukocyte infiltration at inflammatory sites.