GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

xeligekimab   Click here for help

GtoPdb Ligand ID: 13784

Synonyms: GR-1501 | GR1501
Approved drug Immunopharmacology Ligand
xeligekimab is an approved drug
Compound class: Antibody
Comment: Xeligekimab (GR1501) is a human IgG4 monoclonal antibody that targets IL-17A [2].
Bioactivity Comments
Xeligekimab binds human and primate IL-17A with high affinity [2]. It does not bind to mouse IL-17A or other IL-17 family peptides.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-17A Primary target of this compound Hs Antibody Binding 9.9 pKd - 2
⤷ pKd 9.9 (Kd 1.39x10-10 M) [2]
Description: Binding affinity determined by SPR
IL-17A/IL-17F Primary target of this compound Hs Antibody Binding 8.6 pKd - 2
⤷ pKd 8.6 (Kd 2.47x10-9 M) [2]
Description: Binding affinity determined by SPR