lasmotinib   Click here for help

GtoPdb Ligand ID: 13746

Synonyms: PHI-101 | PHI101
Compound class: Synthetic organic
Comment: Lasmotinib is the INN for a tyrosine kinase inhibitor. A structure match in PubChem linked the INN to the company research code PHI-101 (Pharos iBio). PHI-101 has been reported as a FMS-like tyrosine kinase 3 (FLT3) inhibitor [1] and as a checkpoint kinase 2 (Chk2) inhibitor [2], and both of these mechanisms are confirmed by information presented on Pharos iBio's development pipeline page [3]. PHI-101 is proposed for the treatment of various types of cancer. At the time of writing (Feb 2025) the chemical structure of PHI-101 had not been formally disclosed.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 121.55
Molecular weight 386.44
XLogP 1.04
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CC(=CC(=C1)C#CC2=CC(=C(C(=O)N[C@H]3CCCNC3)S2)NC(=O)N)F
Isomeric SMILES C1C[C@@H](CNC1)NC(=O)C2=C(C=C(S2)C#CC3=CC(=CC=C3)F)NC(=O)N
InChI InChI=1S/C19H19FN4O2S/c20-13-4-1-3-12(9-13)6-7-15-10-16(24-19(21)26)17(27-15)18(25)23-14-5-2-8-22-11-14/h1,3-4,9-10,14,22H,2,5,8,11H2,(H,23,25)(H3,21,24,26)/t14-/m0/s1
InChI Key ULVAGWVTXBTFRN-AWEZNQCLSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Nam ZY, Im J, Han JHJHJ, Kim KT, Yoon JH, Cho H, Choi SH, Young D, Nguyen B, Zhu R et al.. (2020)
PHI-101 Is a Potent Third-Generation FLT3 Inhibitor Developed to Overcome Resistance in Acute Myeloid Leukemia.
Blood, 136 (Supplement 1): 28. DOI: 10.1182/blood-2020-139044
2. Park SJ, Chang SJ, Suh DH, Kong TW, Song H, Kim TH, Kim JW, Kim HS, Lee SJ. (2022)
A phase IA dose-escalation study of PHI-101, a new checkpoint kinase 2 inhibitor, for platinum-resistant recurrent ovarian cancer.
BMC Cancer, 22 (1): 28. [PMID:34980026]
3. pharosibio. 
pharosibio pipeline.
Accessed on 20/02/2025. Modified on 20/02/2025. pharosibio.com, https://www.pharosibio.com/en/pipeline