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acyl-CoA-binding protein   Click here for help

GtoPdb Ligand ID: 13696

Synonyms: endozepine [7]
Compound class: Endogenous peptide in human, mouse or rat
Comment: Diazepam binding inhibitor/Acyl-CoA-binding protein (ACBP) an a 11kD peptide with multiple biological actions [1,3,5]. It is reported to bind to thiol esters of long fatty acids and coenzyme A. It also displaces diazepam from the benzodiazepine binding domain of type A gamma-aminobutyric acid GABAA receptors [2,4], which suggests that it may act as an allosteric GABAA modulator.
An in vivo CRISPR activation screening study identified ACBP as a component of a lipid metabolic pathway that is involved in cancer bone metastasis [6].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
endozepine [7]
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
DBI diazepam binding inhibitor, acyl-CoA binding protein Human acyl-CoA-binding protein isoform 1 -
Database Links Click here for help
Ensembl Gene ENSG00000155368 (Hs)
GtoPdb PubChem SID 507750330
Human Protein Atlas ENSG00000155368 (Hs)
OMIM 125950
UniProtKB P07108 (Hs)