Synonyms: MOR-03087 | MOR-202 | MOR03087 | MOR202
Compound class:
Antibody
Comment: Felzartamab (MOR03087; MOR202) is a humanized anti-CD38 monoclonal antibody. It has immunosuppressive action and induces Fc-effector function. Anti-CD38 monoclonals are intended to target long-lived CD38+ autoantibody-secreting plasma cells and plasmablasts that persist in inflamed tissue and bone marrow niches, to mediate immunosuppression.
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Immunopharmacology Comments |
Felzartamab induces potent killing of CD38-expressing lymphoma cells, primarily via antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). |