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dimdazenil   Click here for help

GtoPdb Ligand ID: 13435

Synonyms: EVT-201 | EVT201 | Junoenil®
Compound class: Synthetic organic
Comment: Structurally dimdazenil (EVT-201) is a benzodiazepine derivative. It acts as a partial positive allosteric modulator of the GABAA receptor, with some selectivity for the α1β2γ2 GABAA receptors [2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 73.1
Molecular weight 372.81
XLogP 0.91
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN(C)CC1=NC(=NO1)C2=C3CN(C)C(=O)C4=C(C=CC=C4Cl)N3C=N2
Isomeric SMILES CN1CC2=C(N=CN2C3=C(C1=O)C(=CC=C3)Cl)C4=NOC(=N4)CN(C)C
InChI InChI=1S/C17H17ClN6O2/c1-22(2)8-13-20-16(21-26-13)15-12-7-23(3)17(25)14-10(18)5-4-6-11(14)24(12)9-19-15/h4-6,9H,7-8H2,1-3H3
InChI Key JCYLWUVDHLVGER-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
7-chloro-3-[5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl]-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
International Nonproprietary Names Click here for help
INN number INN
12156 dimdazenil
Synonyms Click here for help
EVT-201 | EVT201 | Junoenil®
Database Links Click here for help
CAS Registry No. 308239-86-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL5095096
DrugBank Ligand DB05721
GtoPdb PubChem SID 500839845
PubChem CID 9885841
Search Google for chemical match using the InChIKey JCYLWUVDHLVGER-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JCYLWUVDHLVGER
Search PubMed clinical trials dimdazenil
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UniChem Compound Search for chemical match using the InChIKey JCYLWUVDHLVGER-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey JCYLWUVDHLVGER-UHFFFAOYSA-N