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Synonyms: ZN148
Compound class:
Synthetic organic
Comment: APC148 (ZN148) is a zinc-chelating β-lactamase inhibitor [1]. It is in clinical development as an adjuvant to be used with reserve group antibacterials for the treatment of patients with complicated Gram-negative infections.
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Bioactivity Comments |
APC148 is an inhibitor of metallo-β-lactamases (MBL). It has been shown to restore the bactericidal activity of meropenem against NDM-1-producing Klebsiella pneumoniae and VIM-2-producing Pseudomonas aeruginosa clinical isolates, and the in vitro susceptibility to carbapenems for a large collection of MBL-producing clinical Enterobacterales strains [1]. |