Jagged2

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Ligands
Jagged2 (Human)

GtoPdb Ligand ID: 13352

Compound class: Endogenous peptide in human, mouse or rat

Comment: This is the mature peptide (minus signal peptide) translated from the human JAG2 gene. It is 1215 amino acids long, with a single-pass transmembrane domain. Jagged2 is an endogenous canonical NOTCH receptor ligand [2,5], from the family that includes the three delta-like (DLL) ligands DLL1, 2 and 4 and Jagged1 and 2 [1].
Targeting Jagged2-mediated NOTCH signalling using an anti-Jagged2 antibody activates macrophage-mediated anti-tumour immunity in lung cancer models [3].

Species: Human

References
1. Chillakuri CR, Sheppard D, Lea SM, Handford PA. (2012) Notch receptor-ligand binding and activation: insights from molecular studies. Semin Cell Dev Biol, 23 (4): 421-8. [PMID:22326375]
2. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J. (1997) Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol, 17 (10): 6057-67. [PMID:9315665]
3. Mandula JK, Sierra-Mondragon RA, Jimenez RV, Chang D, Mohamed E, Chang S, Vazquez-Martinez JA, Cao Y, Anadon CM, Lee SB et al.. (2024) Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages. Immunity, 57 (5): 1124-1140.e9. [PMID:38636522]
4. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H. (2000) Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol, 20 (18): 6913-22. [PMID:10958687]
5. Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI. (1997) JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. Mech Dev, 69 (1-2): 203-7. [PMID:9486542]

References

1. Chillakuri CR, Sheppard D, Lea SM, Handford PA. (2012)
Notch receptor-ligand binding and activation: insights from molecular studies.
Semin Cell Dev Biol, 23 (4): 421-8. [PMID:22326375]

2. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J. (1997)
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.
Mol Cell Biol, 17 (10): 6057-67. [PMID:9315665]

3. Mandula JK, Sierra-Mondragon RA, Jimenez RV, Chang D, Mohamed E, Chang S, Vazquez-Martinez JA, Cao Y, Anadon CM, Lee SB et al.. (2024)
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
Immunity, 57 (5): 1124-1140.e9. [PMID:38636522]

4. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H. (2000)
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.
Mol Cell Biol, 20 (18): 6913-22. [PMID:10958687]

5. Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI. (1997)
JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions.
Mech Dev, 69 (1-2): 203-7. [PMID:9486542]