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exeporfinium   Click here for help

GtoPdb Ligand ID: 13323

Synonyms: XF-73 (exeporfinium chloride)
Compound class: Synthetic organic
Comment: Exeporfinium is a novel dicationic porphyrin antibacterial compound with activity against a wide range of Gram-positive bacteria, including Staphylococcus aureus [2,4]. We show the structure of the parent molecule here. The INN represents the chloride salt form (XF-73, CAS number 718638-68-7) and this is also the form that is under clinical evaluation.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 12
Topological polar surface area 67.24
Molecular weight 694.91
XLogP 3.7
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[N+](C)(C)CCCOC1=CC=C(C=C1)C2=C3C=CC(=N3)C=C4C=CC(=C(C5=CC=C(C=C5)OCCC[N+](C)(C)C)C6=NC(=CC7=CC=C2N7)C=C6)N4
Isomeric SMILES C[N+](C)(C)CCCOC1=CC=C(C=C1)C2=C3C=CC(=CC4=NC(=C(C5=CC=C(N5)C=C6C=CC2=N6)C7=CC=C(C=C7)OCCC[N+](C)(C)C)C=C4)N3
InChI InChI=1S/C44H50N6O2/c1-49(2,3)25-7-27-51-37-17-9-31(10-18-37)43-39-21-13-33(45-39)29-35-15-23-41(47-35)44(42-24-16-36(48-42)30-34-14-22-40(43)46-34)32-11-19-38(20-12-32)52-28-8-26-50(4,5)6/h9-24,29-30,45,48H,7-8,25-28H2,1-6H3/q+2
InChI Key KZTXNPVFWHWJSH-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
trimethyl-[3-[4-[15-[4-[3-(trimethylazaniumyl)propoxy]phenyl]-21,23-dihydroporphyrin-5-yl]phenoxy]propyl]azanium
International Nonproprietary Names Click here for help
INN number INN
9399 exeporfinium chloride
Synonyms Click here for help
XF-73 (exeporfinium chloride)
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo XF-73 (exeporfinium chloride)
Other databases
GtoPdb PubChem SID 496703293
PubChem CID 135456186
Search Google for chemical match using the InChIKey KZTXNPVFWHWJSH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone KZTXNPVFWHWJSH
Search PubMed clinical trials exeporfinium chloride
Search PubMed titles exeporfinium chloride
Search PubMed titles/abstracts exeporfinium chloride
UniChem Compound Search for chemical match using the InChIKey KZTXNPVFWHWJSH-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey KZTXNPVFWHWJSH-UHFFFAOYSA-N