Synonyms: example 27 [WO2018144620] | FT-011 | FT011 | SHP-627
Compound class:
Synthetic organic
Comment: Asengeprast is the INN for a G protein-coupled receptor 68 (GPR68) antagonist with anti-inflammatory potential. We obtained the chemical structure and proposed mechanism of action from INN proposed list 130 (released Feb. 2024). This structure matched to clinical lead FT001 via PubChem, which has proposed anti-inflammatory and anti-fibrotic actions that may be of benefit across a range of human diseases [1-3,6]. Asengeprast's structure was claimed in patent WO2018144620 in 2019 [4].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-[[(E)-3-(3-methoxy-4-prop-2-ynoxyphenyl)prop-2-enoyl]amino]benzoic acid |
International Nonproprietary Names | |
INN number | INN |
13056 | asengeprast |
Synonyms |
example 27 [WO2018144620] | FT-011 | FT011 | SHP-627 |
Database Links | |
CAS Registry No. | 1001288-58-9 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL1075834 |
GtoPdb PubChem SID | 491299984 |
PubChem CID | 23648966 |
Search Google for chemical match using the InChIKey | UIWZIDIJCUEOMT-PKNBQFBNSA-N |
Search Google for chemicals with the same backbone | UIWZIDIJCUEOMT |
Search PubMed clinical trials | asengeprast |
Search PubMed titles | asengeprast |
Search PubMed titles/abstracts | asengeprast |
UniChem Compound Search for chemical match using the InChIKey | UIWZIDIJCUEOMT-PKNBQFBNSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | UIWZIDIJCUEOMT-PKNBQFBNSA-N |