mamba toxin CM-3   Click here for help

GtoPdb Ligand ID: 13153

Synonyms: Adrenergic toxin rho-elapitoxin-Dp1b | rho-EPTX-Dp1b
Compound class: Peptide
Comment: This peptide is a toxin component of black mamba (Dendroaspis polylepis) venom [2]. Its sequence diverges from that of muscarinic toxin β by only two amino acids in its C-terminal. CM-3 has antagonist properties at mammalian adrenoceptors [1].
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Bioactivity Comments
CM-3 does not interact with M3 or M5 muscarinic acetylcholine receptors [1].
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
α1B-adrenoceptor Hs Antagonist Antagonist 8.0 pKi - 1
pKi 8.0 [1]