rucaparib metabolite M324   Click here for help

GtoPdb Ligand ID: 13145

Compound class: Synthetic organic
Comment: M324 is the major metabolite of the PARP inhibitor rucaparib. The metabolite has a unique off-target kinase selectivity profile compared to the parent drug, with M324 potently inhibiting PLK2 and GSK3A [1]; neither of these kinases is so potently inhibited by rucaparib. It is suggested that the combined polypharmacology of the two chemical entities at PARP and kinase targets may offer potential clinically-relevant synergy for tumour therapy.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 78.43
Molecular weight 324.31
XLogP 0.65
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES C1=C(C=CC(=C1)C(=O)O)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F
Isomeric SMILES C1CNC(=O)C2=C3C1=C(NC3=CC(=C2)F)C4=CC=C(C=C4)C(=O)O
InChI InChI=1S/C18H13FN2O3/c19-11-7-13-15-12(5-6-20-17(13)22)16(21-14(15)8-11)9-1-3-10(4-2-9)18(23)24/h1-4,7-8,21H,5-6H2,(H,20,22)(H,23,24)
InChI Key KNTCUVWNFYUDDX-UHFFFAOYSA-N
References
1. Hu H, Serra C, Zhang W, Scrivo A, Fernández-Carasa I, Consiglio A, Aytes A, Pujana MA, Llebaria A, Antolin AA. (2024)
Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite.
Cell Chem Biol, 31 (5): 973-988.e4. [PMID:38335967]