LWY713   Click here for help

GtoPdb Ligand ID: 13116

Synonyms: compound 13ba [PMID: 38007910] | LWY-713
Compound class: Synthetic organic
Comment: LWY713 is a FLT3 PROTAC degrader [1]. It combines a gilteritinib warhead to bind FLT3 with a lenalidomide-based cereblon E3 ubiquitin ligase bait ligand. It effectively induces FLT3 proteasomal degradation, inhibits FLT3 signalling and reduces proliferation in appropriate cellular assays. LWY713 is active in MV4-11 (FLT3-activated cells) xenograft models.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 18
Hydrogen bond donors 4
Rotatable bonds 14
Topological polar surface area 212.83
Molecular weight 838.95
XLogP -0.25
No. Lipinski's rules broken 3

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCC1=NC(=C(NC2=CC=C(C(=C2)OC)N3CCC(CC3)N4CCN(CC4)C(=O)COC5=C6CN(C7CCC(=O)NC7=O)C(=O)C6=CC=C5)N=C1NC8CCOCC8)C(=O)N
Isomeric SMILES CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C(=O)COC5=CC=CC6=C5CN(C6=O)C7CCC(=O)NC7=O)OC)NC8CCOCC8
InChI InChI=1S/C43H54N10O8/c1-3-31-40(45-26-13-21-60-22-14-26)49-41(38(47-31)39(44)56)46-27-7-8-32(35(23-27)59-2)51-15-11-28(12-16-51)50-17-19-52(20-18-50)37(55)25-61-34-6-4-5-29-30(34)24-53(43(29)58)33-9-10-36(54)48-42(33)57/h4-8,23,26,28,33H,3,9-22,24-25H2,1-2H3,(H2,44,56)(H2,45,46,49)(H,48,54,57)
InChI Key RVOJNJLWNBVPOR-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
IUPAC Name Click here for help
3-[4-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxy]acetyl]piperazin-1-yl]piperidin-1-yl]-3-methoxyanilino]-6-ethyl-5-(oxan-4-ylamino)pyrazine-2-carboxamide
Synonyms Click here for help
compound 13ba [PMID: 38007910] | LWY-713
Database Links Click here for help
GtoPdb PubChem SID 491299898
PubChem CID 169450509
Search Google for chemical match using the InChIKey RVOJNJLWNBVPOR-UHFFFAOYSA-N
Search Google for chemicals with the same backbone RVOJNJLWNBVPOR
UniChem Compound Search for chemical match using the InChIKey RVOJNJLWNBVPOR-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey RVOJNJLWNBVPOR-UHFFFAOYSA-N