Synonyms: compound 14h [PMID: 25589934]
Compound class:
Synthetic organic
Comment: Sanofi-14h is a small molecule inhibitor of AGC family kinases such as the serum/glucocorticoid regulated kinases (SGKs) 1 and 3 [3]. It has also been reported to inhibit STING-mediated TANK binding kinase 1 (TBK1) activation independently of SGK1/3 inhibition [2]. This latter report showed that when STING was activated in macrophages, Sanofi-14h inhibited IFNβ production. Functionally Sanofi-14h's mechanism of action included inhibition of SGK activity in conjunction with disruption of the TBK1/IRF3 pathway downstream of STING activation.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,5-dichlorobenzenesulfonamide |
Synonyms |
compound 14h [PMID: 25589934] |
Database Links | |
BindingDB Ligand | 50443635 |
CAS Registry No. | 1426214-64-3 (source: PubChem) |
ChEMBL Ligand | CHEMBL3092461 |
GtoPdb PubChem SID | 491299849 |
PubChem CID | 71537261 |
Search Google for chemical match using the InChIKey | RTERCHJCWXQPSS-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | RTERCHJCWXQPSS |
UniChem Compound Search for chemical match using the InChIKey | RTERCHJCWXQPSS-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RTERCHJCWXQPSS-UHFFFAOYSA-N |