From August 18th 2026, GtoPdb will require users to register to use the website. Please see our blog post for more information.

cerebral dopamine neurotrophic factor   Click here for help

GtoPdb Ligand ID: 13048

Synonyms: arginine-rich, mutated in early stage tumors-like 1 | ARMETL1
Compound class: Endogenous peptide in human, mouse or rat
Comment: CDNF is a dopamine neuron neurotropic factor [5]. It provides cytoprotective effects in neurodegenerative disease models by reducing the activating effect of endoplasmic reticulum stress on the unfolded protein response (UPR) pathway [4,7]. Specifically, CDNF has been shown to protect dopamine neurons and improve motor function in animal Parkinson's disease models [1-2,5-6,8]. However therapeutic use of proteins like CDNF is invasive (intracranial administration) and requires clinical expertise.
Species: Human
No information available.
Summary of Clinical Use Click here for help
The effect of centrally administered CDNF has been investigated in human volunteers with Parkinson's disease [3].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03775538 Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease. Extension to HP-CD-CL-2002 Clinical Study Phase 1/Phase 2 Interventional Herantis Pharma Plc.
NCT03295786 Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease Phase 1/Phase 2 Interventional Herantis Pharma Plc.
NCT04228653 Long-Term Follow-up Safety After DDS Implantation With/Without CDNF Infusions Phase 1/Phase 2 Interventional Renishaw