Compound class:
Synthetic organic
Comment: PCC0105003 is a small molecule inhibitor of microtubule affinity regulating kinases (MARKs) [1]. It has been used to explore the role of these kinases as regulators of neurosynaptic plasticity that acts as a driver of central sensitisation in neuropathic pain.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Shi YQ, Sun ZH, Wang ZZ, Su CY, Zhang W, Yu LY, Xu Y, Gao YL, Wang HB, Tian JW et al.. (2024)
A novel role for microtubule affinity-regulating kinases in neuropathic pain. Br J Pharmacol, 181 (13): 2012-2032. [PMID:38112022] |