GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

BWA-522   Click here for help

GtoPdb Ligand ID: 12912

Synonyms: BWA522 | compound 28 [PMID: 37556600]
Compound class: Synthetic organic
Comment: BWA-522 is an orally active cereblon-targeting PROTAC degrader of the androgen receptor (AR) [2]. It was designed for potential to treat advanced prostate cancer. BWA-522 binds to the N-terminal domain (NTD) of the AR using a warhead derived from the antagonist EPI-002 (ralaniten) [1]. Exploiting the NTD is proposed as a strategy to target both wild type ARs and mutated ARs that have no ligand-binding domain (LBD) and that are therefore unsusceptible to androgen-competitive antagonist drugs.

BWA-522 is commercially available from our sponsors

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 11
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 128.72
Molecular weight 771.34
XLogP 4.49
No. Lipinski's rules broken 3

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES CC(C)(C1=CC=C(C=C1)OCC2CCN(CC2)CC3CCN(CC3)C4=CC=C5C(=C4)C(=O)N(C6CCC(=O)NC6=O)C5=O)C7=CC=C(C=C7)OC[C@@H](CCl)O
Isomeric SMILES ClC[C@H](COC1=CC=C(C=C1)C(C)(C)C2=CC=C(OCC3CCN(CC3)CC4CCN(CC4)C=5C=C6C(N(C(C6=CC5)=O)C7C(NC(CC7)=O)=O)=O)C=C2)O
InChI InChI=1S/C43H51ClN4O7/c1-43(2,31-5-10-35(11-6-31)55-27-33(49)24-44)30-3-8-34(9-4-30)54-26-29-15-19-46(20-16-29)25-28-17-21-47(22-18-28)32-7-12-36-37(23-32)42(53)48(41(36)52)38-13-14-39(50)45-40(38)51/h3-12,23,28-29,33,38,49H,13-22,24-27H2,1-2H3,(H,45,50,51)/t33-,38?/m1/s1
InChI Key MYCPBYLZNZTLBC-OVFDOZPJSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
IUPAC Name Click here for help
5-(4-((4-((4-(2-(4-((S)-3-Chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)methyl)-piperidin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms Click here for help
BWA522 | compound 28 [PMID: 37556600]
Database Links Click here for help
GtoPdb PubChem SID 485206033
PubChem CID 168679672
Search Google for chemical match using the InChIKey MYCPBYLZNZTLBC-OVFDOZPJSA-N
Search Google for chemicals with the same backbone MYCPBYLZNZTLBC
UniChem Compound Search for chemical match using the InChIKey MYCPBYLZNZTLBC-OVFDOZPJSA-N
UniChem Connectivity Search for chemical match using the InChIKey MYCPBYLZNZTLBC-OVFDOZPJSA-N

Product suppliers

View disclaimer

Sponsored products disclaimer

Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

✖

MedChemExpress
BWA-522 (links to external site)
Cat. No. HY-149433