Synonyms: compound 9a [PMID: 37463496] | Mz-438
Compound class:
Synthetic organic
Comment: Mz438 is a fluorescent (TAMRA)-labelled CXCR2 ligand that binds within the receptor's intracellular allosteric binding site [1]. It can be used as a probe in cell-free and cellular assays to investigate CXCR2 pharmacology.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Huber ME, Wurnig S, Toy L, Weiler C, Merten N, Kostenis E, Hansen FK, Schiedel M. (2023)
Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2. J Med Chem, 66 (14): 9916-9933. [PMID:37463496] |