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lamivudine   Click here for help

GtoPdb Ligand ID: 12673

Synonyms: BCH-189 | BCH189 | Epivir® | GR-109714X
Approved drug PDB Ligand
lamivudine is an approved drug (FDA (1995), EMA (1996))
Compound class: Synthetic organic
Comment: Lamivudine is an antiretroviral drug. It inhibits HIV-1 reverse transcriptase, and it belongs to the nucleoside reverse transcriptase inhibitors (NRTI) class of antiretriviral drugs.

lamivudine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 113.45
Molecular weight 229.26
XLogP -1.09
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CN([C@@H]2CS[C@H](CO)O2)C(=O)N=C1N
Isomeric SMILES C1[C@H](O[C@H](S1)CO)N2C=CC(=NC2=O)N
InChI InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
InChI Key JTEGQNOMFQHVDC-NKWVEPMBSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EU EMA (1996)  |  US FDA (1995)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
International Nonproprietary Names Click here for help
INN number INN
6908 lamivudine
Synonyms Click here for help
BCH-189 | BCH189 | Epivir® | GR-109714X
Database Links Click here for help
BindingDB Ligand 50366817
ChEBI CHEBI:63577
ChEMBL Ligand CHEMBL141
DrugBank Ligand DB00709
GtoPdb PubChem SID 483123221
PubChem CID 60825
RCSB PDB Ligand 3TC
Search Google for chemical match using the InChIKey JTEGQNOMFQHVDC-NKWVEPMBSA-N
Search Google for chemicals with the same backbone JTEGQNOMFQHVDC
Search PubMed clinical trials lamivudine
Search PubMed titles lamivudine
Search PubMed titles/abstracts lamivudine
UniChem Compound Search for chemical match using the InChIKey JTEGQNOMFQHVDC-NKWVEPMBSA-N
UniChem Connectivity Search for chemical match using the InChIKey JTEGQNOMFQHVDC-NKWVEPMBSA-N

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

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MedChemExpress
Lamivudine (links to external site)
Cat. No. HY-B0250