Synonyms: compound 16 [PMID: 23472852] | LAU 159 | LAU-159
Compound class:
Synthetic organic
Comment: LAU159 is an allosteric modulator of GABAA receptors [3-4].
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References |
1. Sieghart W, Chiou LC, Ernst M, Fabjan J, M Savic; M, Lee MT. (2022)
α 6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials. Pharmacol Rev, 74 (1): 238-270. [PMID:35017178] |
2. Sieghart W, Savić MM. (2018)
International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans. Pharmacol Rev, 70 (4): 836-878. [PMID:30275042] |
3. Treven M, Siebert DCB, Holzinger R, Bampali K, Fabjan J, Varagic Z, Wimmer L, Steudle F, Scholze P, Schnürch M et al.. (2018)
Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones. Br J Pharmacol, 175 (3): 419-428. [PMID:29127702] |
4. Varagic Z, Wimmer L, Schnürch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W et al.. (2013)
Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. Br J Pharmacol, 169 (2): 371-83. [PMID:23472852] |