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nifurquinazol   Click here for help

GtoPdb Ligand ID: 12344

Synonyms: NF-1088
Compound class: Synthetic organic
Comment: Nifurquinazol is a nitrofuran drug with broad-spectrum antibacterial activity [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 125.76
Molecular weight 344.11
XLogP 1.4
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OCCN(c1nc(nc2c1cccc2)c1ccc(o1)[N+](=O)[O-])CCO
Isomeric SMILES c1ccc2c(c1)c(nc(n2)c1ccc(o1)[N+](=O)[O-])N(CCO)CCO
InChI InChI=1S/C16H16N4O5/c21-9-7-19(8-10-22)16-11-3-1-2-4-12(11)17-15(18-16)13-5-6-14(25-13)20(23)24/h1-6,21-22H,7-10H2
InChI Key AUEOHSUMWXAPBX-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[2-hydroxyethyl-[2-(5-nitrofuran-2-yl)quinazolin-4-yl]amino]ethanol
International Nonproprietary Names Click here for help
INN number INN
2375 nifurquinazol
Synonyms Click here for help
NF-1088
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Nifurquinazol
Other databases
CAS Registry No. 5055-20-9 (source: Scifinder)
ChEMBL Ligand CHEMBL2107101
GtoPdb PubChem SID 479821135
PubChem CID 21139
Search Google for chemical match using the InChIKey AUEOHSUMWXAPBX-UHFFFAOYSA-N
Search Google for chemicals with the same backbone AUEOHSUMWXAPBX
Search PubMed clinical trials nifurquinazol
Search PubMed titles nifurquinazol
Search PubMed titles/abstracts nifurquinazol
UniChem Compound Search for chemical match using the InChIKey AUEOHSUMWXAPBX-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey AUEOHSUMWXAPBX-UHFFFAOYSA-N