bexagliflozin   Click here for help

GtoPdb Ligand ID: 12335

Synonyms: Brenzavvy® | compound 29 [PMID: 21737266] | EGT-0001442 | EGT-1442 | EGT1442 [6] | THR-1442
Approved drug
bexagliflozin is an approved drug (FDA (2023))
Compound class: Synthetic organic
Comment: Bexagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor [5], that was developed for its ability to improve control of blood glucose levels for the treatment of type 2 diabetes [1,6]. It is a C-aryl glucoside class molecule.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 108.61
Molecular weight 464.16
XLogP 2.87
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2ccc(cc2)OCCOC2CC2)Cl)[C@@H]([C@H]([C@@H]1O)O)O
Isomeric SMILES C1CC1OCCOc1ccc(cc1)Cc1c(ccc(c1)[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)Cl
InChI InChI=1S/C24H29ClO7/c25-19-8-3-15(24-23(29)22(28)21(27)20(13-26)32-24)12-16(19)11-14-1-4-17(5-2-14)30-9-10-31-18-6-7-18/h1-5,8,12,18,20-24,26-29H,6-7,9-11,13H2/t20-,21-,22+,23-,24+/m1/s1
InChI Key BTCRKOKVYTVOLU-SJSRKZJXSA-N
No information available.
Summary of Clinical Use Click here for help
Bexagliflozin was granted full FDA approval in January 2023 [4]. It was indicated to improve glycemic control in adults with type 2 diabetes, as an adjunct to diet and exercise.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03115112 Safety and Efficacy of Bexagliflozin Compared to Sitagliptin as Add-on Therapy to Metformin in Type 2 Diabetes Subjects Phase 3 Interventional Theracos 2
NCT02390050 A Dose Range Finding Study to Evaluate the Effect of Bexagliflozin Tablets in Subjects With Type 2 Diabetes Mellitus Phase 2 Interventional Theracos 3