vimnerixin   Click here for help

GtoPdb Ligand ID: 12100

Synonyms: AZD-4721 | AZD4721 | compound 4 [WO2019055509A1] | RIST4721
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Vimnerixin (AZD4721/RIST4721 ) is an orally bioavailable CXC chemokine receptor type 2 antagonist [1]. It has minimal activity on CXCR1, so has little effect on neutrophil activation.

vimnerixin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 158.56
Molecular weight 472.13
XLogP 1.87
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OC[C@@H]([C@H](Oc1cc(nc(n1)SCc1ccc(cc1)F)NS(=O)(=O)N1CC(C1)C)C)O
Isomeric SMILES CC1CN(C1)S(=O)(=O)Nc1cc(nc(n1)SCc1ccc(cc1)F)O[C@H](C)[C@H](CO)O
InChI InChI=1S/C19H25FN4O5S2/c1-12-8-24(9-12)31(27,28)23-17-7-18(29-13(2)16(26)10-25)22-19(21-17)30-11-14-3-5-15(20)6-4-14/h3-7,12-13,16,25-26H,8-11H2,1-2H3,(H,21,22,23)/t13-,16+/m1/s1
InChI Key UCCNQCNIPRKLRP-CJNGLKHVSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
Vimnerixin (RIST4721, AZD4721) has progressed to clinical evaluation in chronic inflammatory conditions.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT01962935 Study to Investigate Safety, Tolerability and Effect of Multiple Dosing With AZD 4721 and/or With AZD 5069 Phase 1 Interventional AstraZeneca
NCT05348681 A Study to Evaluate RIST4721 in Hidradenitis Suppurativa (HS) Phase 2 Interventional Aristea Therapeutics, Inc.
NCT05448391 A Study to Evaluate RIST4721 in Familial Mediterranean Fever (FMF) Phase 2 Interventional Aristea Therapeutics, Inc.
NCT03988335 A Study to Evaluate RIST4721 in Palmoplantar Pustulosis (PPP) Phase 2 Interventional Aristea Therapeutics, Inc. 1