terevalefim   Click here for help

GtoPdb Ligand ID: 11997

Synonyms: ANG-3777 | ANG3777 | Refanalin
Compound class: Synthetic organic
Comment: Terevalefim (ANG-3777) is a clinical stage small molecule hepatocyte growth factor (HGF) mimetic. HGF as a pleiotropic factor with roles in organ regeneration [2-3,5]. Like HGF, terevalefim activates the HGF/c-MET pathway, to promote tissue and organ repair and function. Terevalefim was developed as a first-in-class therapeutic to target acute organ injury.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 56.92
Molecular weight 176.04
XLogP 2.08
No. Lipinski's rules broken 0
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Canonical SMILES c1csc(c1)/C=C/c1[nH]ncc1
Isomeric SMILES c1csc(c1)/C=C/c1ccn[nH]1
InChI InChI=1S/C9H8N2S/c1-2-9(12-7-1)4-3-8-5-6-10-11-8/h1-7H,(H,10,11)/b4-3+
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
11458 terevalefim
Synonyms Click here for help
ANG-3777 | ANG3777 | Refanalin
Database Links Click here for help
CAS Registry No. 1070881-42-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL4650326
GtoPdb PubChem SID 464244138
PubChem CID 5714038
Search Google for chemical match using the InChIKey FOHWAQGURRYJFK-ONEGZZNKSA-N
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UniChem Compound Search for chemical match using the InChIKey FOHWAQGURRYJFK-ONEGZZNKSA-N
UniChem Connectivity Search for chemical match using the InChIKey FOHWAQGURRYJFK-ONEGZZNKSA-N