Synonyms: ANG-3777 | ANG3777 | Refanalin
Compound class:
Synthetic organic
Comment: Terevalefim (ANG-3777) is a clinical stage small molecule hepatocyte growth factor (HGF) mimetic. HGF as a pleiotropic factor with roles in organ regeneration [2-3,5]. Like HGF, terevalefim activates the HGF/c-MET pathway, to promote tissue and organ repair and function. Terevalefim was developed as a first-in-class therapeutic to target acute organ injury.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole |
International Nonproprietary Names ![]() |
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INN number | INN |
11458 | terevalefim |
Synonyms ![]() |
ANG-3777 | ANG3777 | Refanalin |
Database Links ![]() |
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CAS Registry No. | 1070881-42-3 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL4650326 |
GtoPdb PubChem SID | 464244138 |
PubChem CID | 5714038 |
Search Google for chemical match using the InChIKey | FOHWAQGURRYJFK-ONEGZZNKSA-N |
Search Google for chemicals with the same backbone | FOHWAQGURRYJFK |
Search PubMed clinical trials | terevalefim |
Search PubMed titles | terevalefim |
Search PubMed titles/abstracts | terevalefim |
UniChem Compound Search for chemical match using the InChIKey | FOHWAQGURRYJFK-ONEGZZNKSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | FOHWAQGURRYJFK-ONEGZZNKSA-N |
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Terevalefim (links to external site)
Cat. No. HY-137455 |