Synonyms: example 143 [WO2020132269A1] | KSQ4279 | USP1-IN-1
Compound class:
Synthetic organic
Comment: KSQ-4279 is a first-in-class, allosteric inhibitor of the cysteine protease ubiquitin specific peptidase 1 (USP1), that was developed by KSQ Therapeutics as a novel, orally bioavailable cancer therapeutic. It is proposed as a monotherapy or as an adjunct to PARP inhibitor drugs. Its chemical structure was disclosed at the AACR spring meeting in 2022.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine |
Synonyms |
example 143 [WO2020132269A1] | KSQ4279 | USP1-IN-1 |
Database Links | |
CAS Registry No. | 2446480-97-1 (source: PubChem) |
GtoPdb PubChem SID | 464244105 |
PubChem CID | 150782011 |
Search Google for chemical match using the InChIKey | KCBWAFJCKVKYHO-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | KCBWAFJCKVKYHO |
UniChem Compound Search for chemical match using the InChIKey | KCBWAFJCKVKYHO-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KCBWAFJCKVKYHO-UHFFFAOYSA-N |