Synonyms: compound 4 [Garnar-Wortzel et al., 2021]
Compound class:
Synthetic organic
Comment: SR-1114 is an ENL PROTAC degrader that was developed as part of the same study into ENL as an AML therapeutic target as the small molecule inhibitor SR-0813 [1]. Both SR-1114 and SR-0813 disrupt the transcriptional function of ENL. SR-1114 achieves this by directing ENL for cereblon-dependent degradation. SR-1114-induced ENL degradation is rapid, but reversible upon withdrawl of SR-1114, and leads to suppression of multiple ENL target genes (e.g. HOXA10, MYC, MYB, FLT3, ZEB2, and SATB1).
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
N-Cyclobutyl-2-(3-((N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide |
Synonyms ![]() |
compound 4 [Garnar-Wortzel et al., 2021] |
Database Links ![]() |
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GtoPdb PubChem SID | 441604914 |
PubChem CID | 155925846 |
Search Google for chemical match using the InChIKey | WPVVPCVQEBQVLL-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | WPVVPCVQEBQVLL |
UniChem Compound Search for chemical match using the InChIKey | WPVVPCVQEBQVLL-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | WPVVPCVQEBQVLL-UHFFFAOYSA-N |
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SR-1114 (links to external site)
Cat. No. HY-115881 |