GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

bintrafusp alfa   Click here for help

GtoPdb Ligand ID: 11376

Synonyms: M7824 | MSB0011359C
Immunopharmacology Ligand
Compound class: Antibody
Comment: Bintrafusp alfa (M7824) is an investigational bifunctional fusion protein that combines two TGFβ 'trap' domains (derived from the extracellular domain of TGFBR2) that are linked to each of the C-terminal domain of the heavy chains of an anti-PD-L1 IgG1 monoclonal (mAb) [1,3]. The antibody component is similar to the anti-PD-L1 mAb avelumab and similarly, bintrafusp alfa was developed as a cancer immunotherapeutic [5]. Based on evidence that both the TGFβ pathway and the PD-PD-L1/PD-1 immune checkpoint are associated with tumour immune evasion, simultaneous targeting of these pathways was predicted to control tumour growth by restoring and enhancing anti-tumour immune responses [2,4].

Bintrafusp alfa is similar in structure and function to the approved drug retlirafusp alfa.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10665 bintrafusp alfa
Synonyms Click here for help
M7824 | MSB0011359C
Database Links Click here for help
CAS Registry No. 1918149-01-5 (source: WHO INN record)
GtoPdb PubChem SID 440816745
Search PubMed clinical trials bintrafusp alfa
Search PubMed titles bintrafusp alfa
Search PubMed titles/abstracts bintrafusp alfa