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bintrafusp alfa   Click here for help

GtoPdb Ligand ID: 11376

Synonyms: M7824 | MSB0011359C
Immunopharmacology Ligand
Compound class: Antibody
Comment: Bintrafusp alfa (M7824) is an investigational bifunctional fusion protein that combines two TGFβ 'trap' domains (derived from the extracellular domain of TGFBR2) that are linked to each of the C-terminal domain of the heavy chains of an anti-PD-L1 IgG1 monoclonal (mAb) [1,3]. The antibody component is similar to the anti-PD-L1 mAb avelumab and similarly, bintrafusp alfa was developed as a cancer immunotherapeutic [5]. Based on evidence that both the TGFβ pathway and the PD-PD-L1/PD-1 immune checkpoint are associated with tumour immune evasion, simultaneous targeting of these pathways was predicted to control tumour growth by restoring and enhancing anti-tumour immune responses [2,4].

Bintrafusp alfa is similar in structure and function to the approved drug retlirafusp alfa.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
programmed cell death 1 ligand 1 Primary target of this compound Hs Antibody Binding - - - 3
⤷ [3]