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cloxacillin   Click here for help

GtoPdb Ligand ID: 11126

Synonyms: BRL-1621 | BRL1621 | chloroxacillin | Methocillin S | Syntarpen® | Tegopen®
Approved drug PDB Ligand
cloxacillin is an approved drug (FDA (1971))
Compound class: Synthetic organic
Comment: Cloxacillin is a semisynthetic beta-lactamase resistant penicillin antibacterial [1-2]. It has less potent antibacterial activity than benzylpenicillin.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 138.04
Molecular weight 435.07
XLogP 3.04
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OC(=O)[C@@H]1N2C(=O)[C@H]([C@H]2SC1(C)C)NC(=O)c1c(C)onc1c1ccccc1Cl
Isomeric SMILES OC(=O)[C@@H]1N2C(=O)[C@H]([C@H]2SC1(C)C)NC(=O)c1c(C)onc1c1ccccc1Cl
InChI InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1
InChI Key LQOLIRLGBULYKD-JKIFEVAISA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (1971)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
1533 cloxacillin
Synonyms Click here for help
BRL-1621 | BRL1621 | chloroxacillin | Methocillin S | Syntarpen® | Tegopen®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cloxacillin
Other databases
CAS Registry No. 61-72-3 (source: ChemIDplus)
ChEMBL Ligand CHEMBL891
DrugCentral Ligand 720
GtoPdb PubChem SID 434122186
PubChem CID 6098
RCSB PDB Ligand CXN
Search Google for chemical match using the InChIKey LQOLIRLGBULYKD-JKIFEVAISA-N
Search Google for chemicals with the same backbone LQOLIRLGBULYKD
Search PubMed clinical trials cloxacillin
Search PubMed titles cloxacillin
Search PubMed titles/abstracts cloxacillin
UniChem Compound Search for chemical match using the InChIKey LQOLIRLGBULYKD-JKIFEVAISA-N
UniChem Connectivity Search for chemical match using the InChIKey LQOLIRLGBULYKD-JKIFEVAISA-N