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Sch 29482   Click here for help

GtoPdb Ligand ID: 11031

Compound class: Synthetic organic
Comment: Sch 29482 is a penem antibacterial belonging to the β-lactam group. It is orally absorbed, has activity against both Gram-positive and Gram-negative bacteria (with the exception of Pseudomonas) and exhibits β-lactamase stability [1-2,4-5]. Sch 29482 has been dropped from developed for clinical use [3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 128.44
Molecular weight 275.03
XLogP 0.56
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCSC1=C(C(=O)O)N2[C@H](S1)C(C2=O)C(O)C
Isomeric SMILES CCSC1=C(C(=O)O)N2[C@H](S1)C(C2=O)C(O)C
InChI InChI=1S/C10H13NO4S2/c1-3-16-10-6(9(14)15)11-7(13)5(4(2)12)8(11)17-10/h4-5,8,12H,3H2,1-2H3,(H,14,15)/t4?,5?,8-/m1/s1
InChI Key LDVDKTLZRGWFID-MPKXYMLHSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Barry AL, Jones RN, Wilson HW, Badal RE, Thornsberry C. (1982)
Sch 29482, a new oral penem: comparative in-vitro activity, beta-lactamase stability and inhibition.
J Antimicrob Chemother, 9 Suppl C: 97-112. [PMID:6977536]
2. Ganguly AK, Girijavallabhan VM, McCombie S, Pinto P, Rizi R, Jeffrey PD, Lin S. (1982)
Synthesis of Sch 29482--a novel penem antibiotic.
J Antimicrob Chemother, 9 Suppl C: 1-5. [PMID:7061361]
3. Gootz TD. (1990)
Discovery and development of new antimicrobial agents.
Clin Microbiol Rev, 3 (1): 13-31. [PMID:2404566]
4. Hare RS, Miller GH, Naples L, Sabatelli F, Loebenberg D, Waitz JA. (1982)
Sch 29482, a new penem antibiotic: evaluation of in-vitro activity and effect of test conditions.
J Antimicrob Chemother, 9 Suppl C: 7-16. [PMID:7061377]
5. Neu HC, Labthavikul P. (1982)
Antibacterial activity of an oral penem, Sch 29482.
J Antimicrob Chemother, 9 Suppl C: 49-57. [PMID:6977533]