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tigecycline   Click here for help

GtoPdb Ligand ID: 10929

Synonyms: GAR-936 | GAR936 | TBG-MINO | Tygacil® | WAY-GAR-936
Approved drug
tigecycline is an approved drug (FDA (2005), EMA & UK (2006))
Compound class: Synthetic organic
Comment: Tigecycline is a first-in-class glycylcycline (tetracycline) antibacterial derived from minocycline [5,7]. It was designed to overcome efflux and ribosomal protection mechanisms of resistance that have emerged against the tetracycline class of compounds.

tigecycline is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 12
Hydrogen bond donors 7
Rotatable bonds 8
Topological polar surface area 205.76
Molecular weight 585.28
XLogP 1.39
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C(Nc1cc(N(C)C)c2c(c1O)C(=C1[C@@H](C2)C[C@@H]2[C@@](C1=O)(O)C(=C(C(=O)[C@H]2N(C)C)C(=O)N)O)O)CNC(C)(C)C
Isomeric SMILES O=C(Nc1cc(N(C)C)c2c(c1O)C(=C1[C@@H](C2)C[C@@H]2[C@@](C1=O)(O)C(=C(C(=O)[C@H]2N(C)C)C(=O)N)O)O)CNC(C)(C)C
InChI InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36-37,40,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1
InChI Key SOVUOXKZCCAWOJ-HJYUBDRYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. UK MHRA (2006)  |  EU EMA (2006)  |  US FDA (2005)
IUPAC Name Click here for help
(4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
International Nonproprietary Names Click here for help
INN number INN
8115 tigecycline
Synonyms Click here for help
GAR-936 | GAR936 | TBG-MINO | Tygacil® | WAY-GAR-936
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Tigecycline
Other databases
BindingDB Ligand 50247905
CAS Registry No. 220620-09-7 (source: WHO INN record)
ChEMBL Ligand CHEMBL376140
DrugBank Ligand DB00560
GtoPdb PubChem SID 405560370
PubChem CID 54686904
Search Google for chemical match using the InChIKey SOVUOXKZCCAWOJ-HJYUBDRYSA-N
Search Google for chemicals with the same backbone SOVUOXKZCCAWOJ
Search PubMed clinical trials tigecycline
Search PubMed titles tigecycline
Search PubMed titles/abstracts tigecycline
UniChem Compound Search for chemical match using the InChIKey SOVUOXKZCCAWOJ-HJYUBDRYSA-N
UniChem Connectivity Search for chemical match using the InChIKey SOVUOXKZCCAWOJ-HJYUBDRYSA-N

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MedChemExpress
Tigecycline (links to external site)
Cat. No. HY-B0117
(Same CID)