GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

zagotenemab   Click here for help

GtoPdb Ligand ID: 10471

Synonyms: LY-3303560 | LY3303560
Compound class: Antibody
Comment: LY3303560 is a monoclonal antibody that selectively targets tau protein aggregates [1]. It is being developed by Eli Lilly for potential to treat Alzheimer's disease. The primary epitope for LY3303560 is located in the N-terminal region of tau.
Bioactivity Comments
LY3303560 binding affinity (KD) for tau monomer is 235 nM which is approximately 100-fold lower than its affinity for soluble tau aggregate [1]. LY3303560 demonstrated acceptable pharmacokinetic properties in rat and monkey.
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
microtubule associated protein tau {Sp: Human} Peptide Hs Antibody Binding 9.7 pKd - 1
⤷ pKd 9.7 (Kd 2.2x10-10 M) [1]
Description: Binding affinity for soluble tau aggregate by surface plasmon resonance (SPR).