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endothelin-3   Click here for help

GtoPdb Ligand ID: 1004

Abbreviated name: ET-3
Compound class: Endogenous peptide in human, mouse or rat
Comment: The human ET-3 sequence is identical to the mouse and rat ET-3 sequences.
Species: Human, Mouse, Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
ETB receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme
Endothelin-converting enzyme 1
Endothelin-converting enzyme 2
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target
Sp.
Type
Action
Value
Parameter
Reference
ETB receptor Ligand is endogenous in the given species Hs Agonist Full agonist 9.8 – 11.5 pKd - 1-3,5
⤷ pKd 9.8 – 11.5 [1-3,5]
ETB receptor Ligand is endogenous in the given species Rn Agonist Full agonist 9.9 – 10.6 pKd - 5,7
⤷ pKd 9.9 – 10.6 [5,7]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order of endogenous ligands at ETA receptor endothelin-1 (EDN1, P05305) = endothelin-2 (EDN2, P20800) > endothelin-3 (EDN3, P14138) 4
Potency order of endogenous ligands at ETB receptor endothelin-1 (EDN1, P05305) = endothelin-2 (EDN2, P20800), endothelin-3 (EDN3, P14138) 6
Endogenous substrates at Endothelin-converting enzyme 1 endothelin-1 (EDN1, P05305), endothelin-2 (EDN2, P20800), endothelin-3 (EDN3, P14138)
Endogenous substrates at Endothelin-converting enzyme 2 endothelin-1 (EDN1, P05305), endothelin-2 (EDN2, P20800), endothelin-3 (EDN3, P14138)
Ligand mentioned in the following text fields
Endothelin receptors overview
Endothelin receptors comments