ganaplacide [Ligand Id: 9946] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2058833 (Ganaplacide, GNF 156, GNF-156, Kaf156, KAF 156, KAF-156, KAF156) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG channel expressed in CHO cells by patch clamp assay | B | 4.87 | pIC50 | 13400 | nM | IC50 | J Med Chem (2012) 55: 4244-4273 [PMID:22524250] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 transfected with GFP-Luc infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method | F | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2021) 64: 2291-2309 [PMID:33573376] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum assessed as reduction in parasite growth after 72 hrs by SYBR-green based fluorescence assay | F | 7.9 | pEC50 | 12.6 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green fluorescence assay | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2012) 55: 4244-4273 [PMID:22524250] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green fluorescence assay | F | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (2012) 55: 4244-4273 [PMID:22524250] |
| Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium vivax assessed as reduction in parasite growth after 72 hrs by SYBR-green based fluorescence assay | F | 8.26 | pEC50 | 5.5 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
