GKT136901 [Ligand Id: 9935] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1276946
  • cytochrome b-245 beta chain/Cytochrome b-245 heavy chain in Human [ChEMBL: CHEMBL1287627] [GtoPdb: 3002] [UniProtKB: P04839]
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  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cytochrome b-245 beta chain/Cytochrome b-245 heavy chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287627] [GtoPdb: 3002] [UniProtKB: P04839]
ChEMBL Inhibition of human NOX2 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH B 5.82 pKi 1530 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]
GtoPdb Cell free assay of ROS production by NOX2 membranes. - 5.82 pKi 1530 nM Ki J Med Chem (2010) 53: 7715-30 [PMID:20942471]
NADPH oxidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287628] [GtoPdb: 3001] [UniProtKB: Q9Y5S8]
ChEMBL Inhibition of human NOX1 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH B 6.78 pKi 165 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]
GtoPdb Cell free assay of ROS production by NOX1 membranes. - 6.8 pKi 160 nM Ki J Med Chem (2010) 53: 7715-30 [PMID:20942471]
NADPH oxidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250375] [GtoPdb: 3004] [UniProtKB: Q9NPH5]
GtoPdb Cell free assay of ROS production by NOX4 membranes. - 6.78 pKi 165 nM Ki J Med Chem (2010) 53: 7715-30 [PMID:20942471]
ChEMBL Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH B 6.78 pKi 165 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase by in vitro enzymatic assay in presence of xanthine B 4.52 pKi >30000 nM Ki J Med Chem (2010) 53: 7715-7730 [PMID:20942471]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]