xiliertinib [Ligand Id: 9929] activity data from GtoPdb

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  • epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
  • This target only has 1 pki data point
  • 10.3
1 _lig_chart_1 epidermal growth factor receptor Human
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  • erb-b2 receptor tyrosine kinase 4 in Human [GtoPdb: 1799] [UniProtKB: Q15303]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 erb-b2 receptor tyrosine kinase 4 Human
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  • LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 LCK proto-oncogene, Src family tyrosine kinase Human
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  • LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 LYN proto-oncogene, Src family tyrosine kinase Human
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  • tyrosine kinase non receptor 1 in Human [GtoPdb: 2245] [UniProtKB: Q13470]
  • This target only has 0 pki data point
  • 0
5 _lig_chart_5 tyrosine kinase non receptor 1 Human
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  • YES proto-oncogene 1, Src family tyrosine kinase in Human [GtoPdb: 2284] [UniProtKB: P07947]
  • This target only has 0 pki data point
  • 0
6 _lig_chart_6 YES proto-oncogene 1, Src family tyrosine kinase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb - - 10.3 pKi 0.05 nM Ki Oncotarget (2017) 8: 50832-50844 [PMID:28881608]
erb-b2 receptor tyrosine kinase 4 in Human [GtoPdb: 1799] [UniProtKB: Q15303]
GtoPdb - - 6.15 pIC50 705 nM IC50 Oncotarget (2017) 8: 50832-50844 [PMID:28881608]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb - - 6.75 pIC50 176 nM IC50 Oncotarget (2017) 8: 50832-50844 [PMID:28881608]
LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948]
GtoPdb - - 6.3 pIC50 501 nM IC50 Oncotarget (2017) 8: 50832-50844 [PMID:28881608]
tyrosine kinase non receptor 1 in Human [GtoPdb: 2245] [UniProtKB: Q13470]
GtoPdb - - 6.59 pIC50 256 nM IC50 Oncotarget (2017) 8: 50832-50844 [PMID:28881608]
YES proto-oncogene 1, Src family tyrosine kinase in Human [GtoPdb: 2284] [UniProtKB: P07947]
GtoPdb - - 6.48 pIC50 334 nM IC50 Oncotarget (2017) 8: 50832-50844 [PMID:28881608]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.