balamapimod [Ligand Id: 9925] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2104954 (Balamapimod, MKI-833)
  • Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049]
  • This target only has 0 pki data point
  • 0
1 CHEMBL2104954_lig_chart_1 Raf-1 proto-oncogene, serine/threonine kinase Human
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  • SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
  • This target only has 0 pki data point
  • 0
2 CHEMBL2104954_lig_chart_2 SRC proto-oncogene, non-receptor tyrosine kinase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049]
GtoPdb Measuring c-Raf mediated activation of MEK and phosphorylation of MEK substrate. - 6.94 pIC50 114 nM IC50 US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009)
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb Measuring inhibition substrate phosphorylation by p60c-src tyrosine kinase in an ELISA, using an anti-phosphotyrosine detection antibody. - 6.55 pIC50 281 nM IC50 US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009)

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]