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ChEMBL ligand: CHEMBL456341 (Ajulemic acid, Ajulemic Acid, CPL7075, CPL-7075, CT-3, HU-239, IP-751, JBT-101, Lenabasum, Resunab) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
GtoPdb | - | - | 7.49 | pKi | 32.3 | nM | Ki |
J Med Chem (2013) 56: 8224-56 [PMID:23865723]; J Med Chem (1997) 40: 3228-33 [PMID:9379442] |
ChEMBL | Binding affinity to human CB1 receptor | B | 7.49 | pKi | 32.3 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
ChEMBL | Binding affinity to CB1 receptor (unknown origin) | B | 8.24 | pKi | 5.7 | nM | Ki | Bioorg Med Chem (2014) 22: 2830-2843 [PMID:24731541] |
ChEMBL | Agonist activity at CB1 receptor (unknown origin) assessed as cAMP production | F | 6.03 | pEC50 | 927 | nM | EC50 | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
ChEMBL | Binding affinity to human CB2 receptor | B | 6.77 | pKi | 170.5 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
GtoPdb | - | - | 6.77 | pKi | 170 | nM | Ki |
J Med Chem (2013) 56: 8224-56 [PMID:23865723]; J Med Chem (1997) 40: 3228-33 [PMID:9379442] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]