macimorelin [Ligand Id: 9745] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL278623 (AEZS-130, Ard-07, ARD-07, EP-01572, EP01572, EP-1572, JMV 1843, JMV-1843, Macimorelin, Macrilen, Solorel) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] | ||||||||
| ChEMBL | Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand | B | 6.91 | pIC50 | 123 | nM | IC50 | J Med Chem (2003) 46: 1191-1203 [PMID:12646029] |
| ChEMBL | Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand | B | 7.64 | pIC50 | 22.9 | nM | IC50 | J Med Chem (2003) 46: 1191-1203 [PMID:12646029] |
| GtoPdb | In a radioligand displacement assay using 125I-labeled ghrelin as the probe, and human pituitary gland samples. | - | 7.81 | pIC50 | 15.6 | nM | IC50 | J Endocrinol Invest (2002) 25: RC26-8 [PMID:12240910] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
