MMV048 [Ligand Id: 9726] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2041980 (J3.367.891F, MMV-048, MMV048, Mmv-390048, MMV-390048) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Inhibition of human ERG expressed in CHO cells by IonWorks assay | B | 5.33 | pIC50 | 4700 | nM | IC50 | J Med Chem (2012) 55: 3479-3487 [PMID:22390538] |
| Plasmodium cynomolgi (target type: ORGANISM) [ChEMBL: CHEMBL613883] | ||||||||
| ChEMBL | Antimalarial activity against hypnozoites stage Plasmodium cynomolgi infected in primary rhesus monkey hepatocytes measured on day 5 | F | 5 | pEC50 | >10000 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Antimalarial activity against schizont stage Plasmodium cynomolgi infected in primary rhesus monkey hepatocytes | F | 7.19 | pEC50 | 64 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Antimalarial activity against hypnozoites stage Plasmodium cynomolgi infected in primary rhesus monkey hepatocytes | F | 7.21 | pEC50 | 61 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring PI4K S743T mutant | F | 7.06 | pIC50 | 88 | nM | IC50 | J Med Chem (2018) 61: 4213-4227 [PMID:29665687] |
| ChEMBL | Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 transfected with GFP-Luc infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method | F | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2021) 64: 2291-2309 [PMID:33573376] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum NF54 after 24 to 72 hrs | F | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2018) 61: 8061-8077 [PMID:29771541] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 after 24 hrs by hypoxanthine incorporation assay | F | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2012) 55: 3479-3487 [PMID:22390538] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 | F | 7.75 | pIC50 | 17.8 | nM | IC50 | Eur J Med Chem (2013) 66: 314-323 [PMID:23811093] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition by lactate dehydrogenase assay | F | 7.75 | pIC50 | 17.8 | nM | IC50 | J Med Chem (2014) 57: 435-448 [PMID:24354322] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum D10 assessed as parasite growth inhibition by lactate dehydrogenase assay | F | 8.05 | pIC50 | 9.01 | nM | IC50 | J Med Chem (2014) 57: 435-448 [PMID:24354322] |
| ChEMBL | Antimalarial activity against wild type Plasmodium falciparum Dd2 | F | 8.28 | pIC50 | 5.2 | nM | IC50 | J Med Chem (2018) 61: 4213-4227 [PMID:29665687] |
| ChEMBL | Antimalarial activity against early stage Plasmodium falciparum gametocytes by luciferase reporter gene assay | F | 6.67 | pEC50 | 214 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Antimalarial activity against late stage Plasmodium falciparum gametocytes by luciferase reporter gene assay | F | 6.85 | pEC50 | 140 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Antimalarial activity against stage 5 Plasmodium falciparum assessed as reduction in oocyst formation in mosquito midgut pretreated 24 hrs before feeding by standard membrane-feeding assay | F | 6.95 | pEC50 | 111 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Antimalarial activity against late stage Plasmodium falciparum gametocytes assessed as reduction in gametogenesis exflagellation after 24 hrs | F | 7.05 | pEC50 | 90 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Ex-vivo antimalarial activity against Plasmodium falciparum serum derived from 40 mg, po treated human after 144 hrs | F | 7.62 | pEC50 | 24 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by hypoxanthine incorporation assay | F | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (2012) 55: 3479-3487 [PMID:22390538] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium cynomolgi [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 5 | pIC50 | >10000 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
| GtoPdb | Parasite liver stage assay | - | 7.19 | pIC50 | 64 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
| GtoPdb | Parasite liver stage assay | - | 7.21 | pIC50 | 61 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum [GtoPdb: 2972] | ||||||||
| GtoPdb | - | - | 6.52 | pKd | 300 | nM | Kd | Sci Transl Med (2017) 9: [PMID:28446690] |
| GtoPdb | - | - | 7 | pKd | 100 | nM | Kd | Sci Transl Med (2017) 9: [PMID:28446690] |
| GtoPdb | Standard membrane feeding assay (SMFA) | - | 6.95 | pIC50 | 111 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite gametocyte viability assay | - | 6.55 | pIC50 | 285 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
| GtoPdb | Parasite gametocyte viability assay | - | 6.67 | pIC50 | 214 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
| GtoPdb | Parasite gametocyte viability assay | - | 6.85 | pIC50 | 140 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
| GtoPdb | Parasite growth inhibition assay | - | 7.55 | pIC50 | 28 | nM | IC50 | Sci Transl Med (2017) 9: [PMID:28446690] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
