compound III [PMID: 24045148] [Ligand Id: 9709] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL3770411
  • mPGES1/Prostaglandin E synthase in Human [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
  • mPGES1 in Rat [GtoPdb: 1377]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
GtoPdb Vs. recombinant human mPGES-1. - 6.74 pIC50 180 nM IC50 WO2011023812. Microsomal prostaglandin e synthase-1 (mpges1) inhibitors (2011)
ChEMBL Inhibition of human microsomal PGES1 using PGH2 as substrate incubated for 90 secs by MDA-TBA assay B 7.05 pIC50 90 nM IC50 MedChemComm (2015) 6: 2081-2123
GtoPdb Vs. recombinant human mPGES-1. - 7.05 pIC50 90 nM IC50 Prostaglandins Other Lipid Mediat (2013) 107: 26-34 [PMID:24045148]
mPGES1 in Rat [GtoPdb: 1377]
GtoPdb Vs. recombinant rat mPGES-1. - 6.04 pIC50 920 nM IC50 WO2011023812. Microsomal prostaglandin e synthase-1 (mpges1) inhibitors (2011)
GtoPdb Vs. recombinant rat mPGES-1. - 6.05 pIC50 900 nM IC50 Prostaglandins Other Lipid Mediat (2013) 107: 26-34 [PMID:24045148]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]