compound III [PMID: 24045148] [Ligand Id: 9709] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3770411 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] | ||||||||
| GtoPdb | Vs. recombinant human mPGES-1. | - | 6.74 | pIC50 | 180 | nM | IC50 | WO2011023812. Microsomal prostaglandin e synthase-1 (mpges1) inhibitors (2011) |
| ChEMBL | Inhibition of human microsomal PGES1 using PGH2 as substrate incubated for 90 secs by MDA-TBA assay | B | 7.05 | pIC50 | 90 | nM | IC50 | Medchemcomm (2015) 6: 2081-2123 |
| GtoPdb | Vs. recombinant human mPGES-1. | - | 7.05 | pIC50 | 90 | nM | IC50 | Prostaglandins Other Lipid Mediat (2013) 107: 26-34 [PMID:24045148] |
| mPGES1 in Rat [GtoPdb: 1377] | ||||||||
| GtoPdb | Vs. recombinant rat mPGES-1. | - | 6.04 | pIC50 | 920 | nM | IC50 | WO2011023812. Microsomal prostaglandin e synthase-1 (mpges1) inhibitors (2011) |
| GtoPdb | Vs. recombinant rat mPGES-1. | - | 6.05 | pIC50 | 900 | nM | IC50 | Prostaglandins Other Lipid Mediat (2013) 107: 26-34 [PMID:24045148] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
