(+)-AJ76 [Ligand Id: 970] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL27441
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • Dopamine D2 receptor in Bovine [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd BovinepKi BovinepIC50 BovinepEC50 BovinepKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • D3 receptor in Rat [GtoPdb: 216] [UniProtKB: P19020]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
Created with Highcharts 10.3.3ValuesChart context menuDopamine D4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 1a (5-HT1a) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 5a (5-HT5a) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity was measured at cloned mammalian dopamine D2 receptor expressed in CHO-K1 cells (using [3H]U-86170) B 6.84 pKi 145 nM Ki Bioorg Med Chem Lett (1994) 4: 689-694
ChEMBL Compound was tested for agonistic activity against D2 receptor from cloned CHO cells, used [3H]U-86170 as radioligand F 7.85 pKi 14 nM Ki J Med Chem (1993) 36: 1301-1315 [PMID:8496900]
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
ChEMBL Evaluated for binding towards Dopamine receptor D2 using [3H]-spiperone as radioligand, in cloned mammalian receptors expressed in CHO-K1 cells B 6.8 pKi 158 nM Ki J Med Chem (1993) 36: 3188-3196 [PMID:8230107]
ChEMBL Binding towards Dopamine receptor D2 expressed in CHO-K1 cells using [3H]U-86170 B 6.84 pKi 145 nM Ki J Med Chem (1993) 36: 3188-3196 [PMID:8230107]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Binding towards Dopamine receptor D2 using [3H]spiperone from rat striatal membrane B 6.28 pKi 530 nM Ki J Med Chem (1993) 36: 3188-3196 [PMID:8230107]
ChEMBL Evaluated for binding towards Dopamine receptor D2 using [3H]N-0437 as radioligand from rat striatal membrane B 6.52 pKi 300 nM Ki J Med Chem (1993) 36: 3188-3196 [PMID:8230107]
ChEMBL Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligand F 6.75 pKi 179 nM Ki J Med Chem (1993) 36: 1301-1315 [PMID:8496900]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb - - 6.2 pKi - - - Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163];
J Pharmacol Exp Ther (1995) 275: 885-898 [PMID:7473180]
ChEMBL Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells B 7.15 pKi 70 nM Ki J Med Chem (2003) 46: 4377-4392 [PMID:14521403]
ChEMBL Binding towards Dopamine receptor D3 expressed in CHO-K1 cells using [3H]spiperone B 7.59 pKi 26 nM Ki J Med Chem (1993) 36: 3188-3196 [PMID:8230107]
ChEMBL Binding affinity was measured at cloned mammalian dopamine D3 receptor expressed in CHO-K1 cells (using [3H]- spiperone) B 7.59 pKi 26 nM Ki Bioorg Med Chem Lett (1994) 4: 689-694
D3 receptor in Rat [GtoPdb: 216] [UniProtKB: P19020]
GtoPdb - - 6 pKi - - - Nature (1990) 347: 146-51 [PMID:1975644]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding towards dopamine receptor D4 expressed in CHO-K1 cells using [3H]spiperone B 6.93 pKi 117 nM Ki J Med Chem (1993) 36: 3188-3196 [PMID:8230107]
ChEMBL Binding affinity was measured at cloned mammalian dopamine D4 receptor expressed in CHO-K1 cells (using [3H]- spiperone) B 6.93 pKi 117 nM Ki Bioorg Med Chem Lett (1994) 4: 689-694
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligand B 6.39 pKi 410 nM Ki J Med Chem (1993) 36: 1301-1315 [PMID:8496900]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL Binding affinity was measured at cloned mammalian 5-HT1A receptor expressed in CHO-K1 cells (using [3H]8-OH-DPAT ) B 5.63 pKi 2331 nM Ki Bioorg Med Chem Lett (1994) 4: 689-694

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]