trans-flupenthixol [Ligand Id: 968] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL42055 (E-flupentixol, Flupenthixol, Flupentixole)
  • Dopamine D1 receptor in Bovine [ChEMBL: CHEMBL2967] [UniProtKB: Q95136]
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
  • 7.42
1 CHEMBL42055_lig_chart_1 Dopamine D1 receptor BovineRat
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • This target only has 0 pki data point
  • 0
2 CHEMBL42055_lig_chart_2 Sigma opioid receptor Human
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  • D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
  • This target only has 1 pki data point
  • 6.92
3 CHEMBL42055_lig_chart_3 D2 receptor Human
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  • D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
  • 6.52
4 CHEMBL42055_lig_chart_4 D3 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136]
ChEMBL Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined B 7.74 pKi 18 nM Ki J. Med. Chem. (1997) 40: 952-960 [PMID:9083484]
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate B 7.42 pKi 37.8 nM Ki J. Med. Chem. (1998) 41: 3763-3772 [PMID:9748351]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL The compound was tested for affinity towards sigma-3 receptor B 7.83 pIC50 14.79 nM IC50 J. Med. Chem. (1994) 37: 4109-4117 [PMID:7990111]
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 6.92 pKi 120 nM Ki J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb - - 6.52 pKi 300 nM Ki J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]