compound 28 [PMID: 28671460] [Ligand Id: 9670] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL581893 (GNF-Pf-3346)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Lactoperoxidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2295561] [UniProtKB: P80025]
ChEMBL Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 mins B 5.49 pIC50 3200 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL Inhibition of MPO in human neutrophils assessed as reduction in HOCl production preincubated for 30 mins followed by H2O2 addition by APF staining based flow cytometry B 4.03 pIC50 93100 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
ChEMBL Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA B 7.05 pIC50 90 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
ChEMBL Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins B 7.36 pIC50 44 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
GtoPdb - - 7.36 pIC50 44 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay F 5.99 pEC50 1016 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay F 6.38 pEC50 417 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]