ChEMBL ligand: CHEMBL511749
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of recombinant human HDAC1 using Ac-RHKK(Ac)-ACC as substrate by fluorometric analysis	B	5.45	pIC50	3567	nM	IC50	Bioorg Med Chem Lett (2010) 20: 7067-7070 [PMID:20947351]
ChEMBL	Inhibition of recombinant human HDAC1 using Cbz-Lys(TFAc)-AMC as substrate by fluorometric analysis	B	6.47	pIC50	340	nM	IC50	Bioorg Med Chem Lett (2010) 20: 7067-7070 [PMID:20947351]
ChEMBL	Inhibition of HDAC1 after 17 hrs	B	6.57	pIC50	271	nM	IC50	J Med Chem (2008) 51: 4370-4373 [PMID:18642892]
ChEMBL	Inhibition of recombinant human HDAC1 expressed in baculovirus expression system using Ac-Leu-Gly-Lys (Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence microtiter plate reader assay	B	6.59	pIC50	260	nM	IC50	J Med Chem (2022) 65: 2434-2457 [PMID:35043615]
GtoPdb	-	-	7	pIC50	100	nM	IC50	J Med Chem (2008) 51: 4370-3 [PMID:18642892]
ChEMBL	Inhibition of HDAC1 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence-based electrophoretic assay	B	7.9	pIC50	12.7	nM	IC50	J Med Chem (2013) 56: 6297-6313 [PMID:23627282]
ChEMBL	Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2019) 62: 8557-8577 [PMID:31414801]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL	Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter gene-based BRET assay	B	6.1	pIC50	794.33	nM	IC50	J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
ChEMBL	Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assay	B	6.5	pIC50	316.23	nM	IC50	J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
ChEMBL	Inhibition of HDAC10 after 17 hrs	B	7.04	pIC50	90.7	nM	IC50	J Med Chem (2008) 51: 4370-4373 [PMID:18642892]
GtoPdb	-	-	7.55	pIC50	28.2	nM	IC50	J Med Chem (2008) 51: 4370-3 [PMID:18642892]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
ChEMBL	Inhibition of HDAC2 after 17 hrs	B	6.6	pIC50	252	nM	IC50	J Med Chem (2008) 51: 4370-4373 [PMID:18642892]
GtoPdb	-	-	6.62	pIC50	238	nM	IC50	J Med Chem (2008) 51: 4370-3 [PMID:18642892]
ChEMBL	Inhibition of HDAC2 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence-based electrophoretic assay	B	7.03	pIC50	93	nM	IC50	J Med Chem (2013) 56: 6297-6313 [PMID:23627282]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL	Inhibition of recombinant human His-tagged HDAC3 expressed in baculovirus insect cells using Ac-Leu-Gly-Lys (Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence microtiter plate reader assay	B	6.12	pIC50	760	nM	IC50	J Med Chem (2022) 65: 2434-2457 [PMID:35043615]
ChEMBL	Inhibition of HDAC3 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence-based electrophoretic assay	B	6.72	pIC50	190	nM	IC50	J Med Chem (2013) 56: 6297-6313 [PMID:23627282]
GtoPdb	-	-	8.7	pIC50	<2	nM	IC50	J Med Chem (2008) 51: 4370-3 [PMID:18642892]
ChEMBL	Inhibition of HDAC3 after 17 hrs	B	9.38	pIC50	0.42	nM	IC50	J Med Chem (2008) 51: 4370-4373 [PMID:18642892]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate by fluorometric analysis	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2010) 20: 7067-7070 [PMID:20947351]
ChEMBL	Inhibition of recombinant human HDAC6 using Ac-RHKK(Ac)-ACC as substrate by fluorometric analysis	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (2010) 20: 7067-7070 [PMID:20947351]
ChEMBL	Inhibition of recombinant human N-terminal GST tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys (Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence microtiter plate reader assay	B	7.74	pIC50	18	nM	IC50	J Med Chem (2022) 65: 2434-2457 [PMID:35043615]
ChEMBL	Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay	B	7.86	pIC50	13.8	nM	IC50	J Med Chem (2019) 62: 8557-8577 [PMID:31414801]
GtoPdb	-	-	8.7	pIC50	<2	nM	IC50	J Med Chem (2008) 51: 4370-3 [PMID:18642892]
ChEMBL	Inhibition of HDAC6 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by fluorescence-based electrophoretic assay	B	9.49	pIC50	0.33	nM	IC50	J Med Chem (2013) 56: 6297-6313 [PMID:23627282]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
GtoPdb	-	-	5.09	pIC50	8104	nM	IC50	J Med Chem (2008) 51: 4370-3 [PMID:18642892]
ChEMBL	Inhibition of HDAC8 after 17 hrs	B	5.16	pIC50	6851	nM	IC50	J Med Chem (2008) 51: 4370-4373 [PMID:18642892]
ChEMBL	Inhibition of full length recombinant human C-terminal His tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-GlyLys (Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence microtiter plate reader assay	B	5.21	pIC50	6210	nM	IC50	J Med Chem (2022) 65: 2434-2457 [PMID:35043615]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]