delgocitinib [Ligand Id: 9619] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| GtoPdb | In an assay using the kinase domain of the recombinant human enzyme, a biotinylated peptide substrate, and [33P]ATP. | - | 8.68 | pKi | 2.1 | nM | Ki | Inflamm Res (2015) 64: 41-51 [PMID:25387665] |
| GtoPdb | - | - | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2020) 63: 7163-7185 [PMID:32511913] |
| Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| GtoPdb | In an assay using the kinase domain of the recombinant human enzyme, a biotinylated peptide substrate, and [33P]ATP. | - | 8.77 | pKi | 1.7 | nM | Ki | Inflamm Res (2015) 64: 41-51 [PMID:25387665] |
| GtoPdb | - | - | 8.59 | pIC50 | 2.6 | nM | IC50 | J Med Chem (2020) 63: 7163-7185 [PMID:32511913] |
| Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| GtoPdb | In an assay using the kinase domain of the recombinant human enzyme, a biotinylated peptide substrate, and [33P]ATP. | - | 8.26 | pKi | 5.5 | nM | Ki | Inflamm Res (2015) 64: 41-51 [PMID:25387665] |
| GtoPdb | - | - | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2020) 63: 7163-7185 [PMID:32511913] |
| tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| GtoPdb | In an assay using the kinase domain of the recombinant human enzyme, a biotinylated peptide substrate, and [33P]ATP. | - | 7.85 | pKi | 14 | nM | Ki | Inflamm Res (2015) 64: 41-51 [PMID:25387665] |
| GtoPdb | - | - | 7.24 | pIC50 | 58 | nM | IC50 | J Med Chem (2020) 63: 7163-7185 [PMID:32511913] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
