atracurium [Ligand Id: 9537] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1360 (Atracurium, Tracrium)
  • KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605]
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  • nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
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  • nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297]
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  • nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681]
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  • nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605]
ChEMBL Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique B 5.19 pKd 6400 nM Kd J. Med. Chem. (2008) 51: 7625-7634 [PMID:18998663]
ChEMBL Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells B 5.23 pKi 5900 nM Ki J. Med. Chem. (2008) 51: 7625-7634 [PMID:18998663]
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
GtoPdb Antagonism of ACh activation of α1β1εδ nACh receptors expressed in Xenopus oocytes. - 7.01 pIC50 97 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297]
GtoPdb Antagonism of ACh activation of human α3β2 or α3β4 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. - 9.05 pIC50 0.9 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681]
GtoPdb Antagonism of ACh activation of human α4β2 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. - 8.1 pIC50 7.9 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544]
GtoPdb Antagonism of ACh activation of human α7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. - 8.25 pIC50 5.6 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]