atracurium [Ligand Id: 9537] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1360 (Atracurium, Atracurium cation, Atracurium ion, Tracrium) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] | ||||||||
| ChEMBL | Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique | B | 5.19 | pKd | 6400 | nM | Kd | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| ChEMBL | Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells | B | 5.23 | pKi | 5900 | nM | Ki | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708] | ||||||||
| GtoPdb | Antagonism of ACh activation of α1β1εδ nACh receptors expressed in Xenopus oocytes. | - | 7.01 | pIC50 | 97 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
| nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297] | ||||||||
| GtoPdb | Antagonism of ACh activation of human α3β2 or α3β4 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. | - | 9.05 | pIC50 | 0.9 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
| nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681] | ||||||||
| GtoPdb | Antagonism of ACh activation of human α4β2 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. | - | 8.1 | pIC50 | 7.9 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
| nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544] | ||||||||
| GtoPdb | Antagonism of ACh activation of human α7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. | - | 8.25 | pIC50 | 5.6 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
