atracurium [Ligand Id: 9537] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1360 (Atracurium, Atracurium cation, Atracurium ion, Tracrium) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] | ||||||||
| ChEMBL | Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique | B | 5.19 | pKd | 6400 | nM | Kd | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| ChEMBL | Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells | B | 5.23 | pKi | 5900 | nM | Ki | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708] | ||||||||
| GtoPdb | Antagonism of ACh activation of α1β1εδ nACh receptors expressed in Xenopus oocytes. | - | 7.01 | pIC50 | 97 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
| nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297] | ||||||||
| GtoPdb | Antagonism of ACh activation of human α3β2 or α3β4 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. | - | 9.05 | pIC50 | 0.9 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
| nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681] | ||||||||
| GtoPdb | Antagonism of ACh activation of human α4β2 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. | - | 8.1 | pIC50 | 7.9 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
| nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544] | ||||||||
| GtoPdb | Antagonism of ACh activation of human α7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. | - | 8.25 | pIC50 | 5.6 | nM | IC50 | Anesthesiology (2006) 105: 521-33 [PMID:16931985] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
